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Table 1 Summary of studies on CIN, cervical cancer, and HLA

From: Association Between HLA DQBl * 03 and Cervical Intra-epithelial Neoplasia

Study

Patients

Controls

Population

HLA Typing Method

HPV Typing

Results

Wank and Thomssen (1991) (1)

66 (SCC)

109 (local panel)

German

Serology

Not done

1. DQW3: RR = 7.1 2. DR5: Increased risk 3. DR6: Decreased RR 12.7

Wank et al. (1992) (32)

66 (SCC)

109 (local panel)

German

PCR-SSO

Not done

Increased risk of SCC for DQB1 * 0301 & 0303

Heiland et al. (1992) (26)

213 (SCC)

181 (local panel)

Norwegian

PCR-SSO

Not done

DQW3: RR = 2.0

Vandenvelde et al. (1993) (32)

71 (CIN)

323 (CINO, not typed for HPV)

Belgian

PCR-ASO

Method and HPV types not stated

DQB1 * 03: RR = 2.647 for HPV-associated CIN

David et al. (1993) (29)

50 (CIN)

99 (CINO, blood donors)

British

PCR-SSO

Not done

DQB1 * 03: RR = 2.5 for CIN III

Glew et al. (1993) (30)

65 (SCC)

857 (organ donors)

British

PCR-SSO & Serology

Southern blotting, HPV 16 only

No HLA association

Apple et al. (1994) (27)

98 (SCC)

220 (CINO, includes HPV-positive women)

Hispanic

PCR-SSO

PCR consensus primers and oligonucleotide probing

1. DRB1 * 1501-DQB1 * 0602 OR = 4.78 for HPV 16 +ve cases 2. DRB1 * 0407-DQB1 * 0302 OR = 2.19 3. DR13: OR = 0.29 (−ve) 4. DQB1 * 03: No association

Gregoire et al. (1994) (31)

66 (SCC)

214 (local panel, not typed for HPV)

African-American

PCR-SSO

PCR consensus primers and oligonucleotide probing

1. DQB1 * 03: RR = 2.3 2. DQB1 * 0303: RR = 5.2 3. DQB1 * 0604: RR = 5.2

  1. RR = relative risk; OR = odds ratio; SCC = squamous cell carinoma.