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Fig. 1 | Molecular Medicine

Fig. 1

From: Nuclear Localization Signal of HIV-1 as a Novel Target for Therapeutic Intervention

Fig. 1

Presumed interaction of anti-NLS compounds with HIV-1 MA p17 NLS

One of the anti-NLS compounds, H-0294, is shown. Reversible reaction of a carbonyl group with an amino group of any lysine (including those within the MA p17 NLS) results in the formation of a Schiff base. Formation of two Schiff bases after reaction with the adjacent lysines characteristic of nuclear localization signals would stabilize the bimolecular complex, shifting the equilibrium toward product formation.

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Molecular Medicine

ISSN: 1528-3658