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Table 1 Clinical parameters of at-risk subjects

From: Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

Subject #

Age

Years Follow-Up

HLA

ICAa

IAAb

GAD Abc

FPIRd

A

B

DR

DQ

1

14

1.6

1

8

3

2

160,69,56

4,30,×20

 

118,155

2

23

4.8

2

44,55

3,4

5,8

55,37,14,6,5,5

×25,9,41,×2,0,44

278,602

124,113,57

3

22

6.8

2,28

7,8

3,4

2,8

37,37,37,37,52,30, 58,46,26

8,9,2,31,7,9,×41,×1,64

1637,2259,634,1535

183,155,140,161,56

4

13

1.3

1,11

8,27

3,4

2,8

160,190

84,280

 

79,91

5

25

5.5

2

44,62

4,11

7,8

0,19,18,16,22,0,0

45,31,42,60,29,130,30

736,936,1336,790,810

137,143,68,15

6

20

5.5

1,2

8,62

3,4

2,8

19,19,104,86,8

480,560,400,130,300

937,2258,2389

105,238,165,128

7

18

1.7

1,3

8,18

3

2

69,69

13,20

 

44,47

8

9

3.2

1,2

8,44

3,4

2,8

160,160,160,160

×2,×26,36,59

2300,1830

118,129,87

9

10

2.8

1,2

8,27

3,4

2,8

160,160,120,24

2,29,14,120

1525,1388

26,56,29

10

14

4.8

1,32

8,14

4,7

2,8

14,13,51,18

240,490,470,1000

432

318,181,165

  1. aICA, Islet cell antibody titres (JDF units).
  2. bIAA, Insulin autoantibody titres (nU insulin bound/ml serum).
  3. cGAD Ab, Glutamic acid decarboxylase autoantibody titres (nU/ml).
  4. dFPIR, First phase insulin release (sum of serum insulin concentrations at 1 and 3 min following completion of glucose injection).