Fig. 2
Clinicopathologic correlates of CK2 activity in squamous cell carcinoma of the head and neck
Clinicopathologic correlates of CK2 activity in cytosolic fractions of SCCHN. CK2 activity was measured in cytosolic fractions of SCCHN tumors using the CK2-specific decapeptide substrate, and activity presented as nanomoles 32P transferred to substrate per hour incubation per milligram protein in sample, as described in Materials and Methods. (A) CK2 activity is displayed by histopathologic differentiation: moderate differentiation (n = 11; open bar) vs. poor differentiation (n = 7; shaded bar); p < 0.037. Well-differentiated tumors were not included in the analysis due to low n (n = 2). (B) CK2 activity displayed by nodal status: node-negative (n = 9; open bar) versus node-positive (n = 11; shaded bar); p < 0.056. (C) CK2 activity displayed by clinical outcome: alive free of disease (n = 13; open bar) versus dead of disease (n = 7; shaded bar); p < 0.028. All data are plotted as the mean ± SEM.