Molecular Medicine

Table 1 Analytical characterization of the Dmt-Tic and Tyr-Tic peptides

From: δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides

			R_t
Peptide	R	R′	A	B	K′	MH ⁺
1. H-Dmt-Tic	OH	−	0.66	0.23	5.83	368
2. H-Dmt-Tic	NH₂	−	0.69	0.43	6.32	367
3. H-Dmt-d-Tic	OH	−	0.61	0.16	5.83	368
4. H-Dmt-d-Tic	NH₂	−	0.64	0.45	0.45	367
5. H-Dmt-Tic	CH₂OH	−	0.67	0.51	7.27	354
6. H-Tyr-Tic	OH	−	0.62	0.21	3.61	340
8. H-Tyr-d-Tic	OH	−	0.61	0.21	3.62	340
10. H-Tyr-Tic	CH₂OH	−	0.66	0.45	4.23	326
11. H-Dmt-Tic	Ala	OH	0.73	0.26	8.68	440
12. H-Dmt-Tic	Ala	NH₂	0.67	0.43	9.31	439
13. H-Dmt-d-Tic	Ala	OH	0.64	0.27	6.78	440
14. H-Dmt-d-Tic	Ala	NH₂	0.66	0.41	8.81	439
17. Tyr-d-Tic	Ala	OH	0.63	0.19	4.24	411

The TLC solvent systems (A and B) are given in Materials and Methods. The capacity factor, K′, is determined by analytical HPLC. The mass ion, MH⁺, of each peptide was determined by FAB-MS. The missing peptides (peptides 7, 9, 15, 16, and 18) (c.f., Table 2) were published elsewhere (18). R and R′ are substituents.

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ISSN: 1528-3658

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