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Fig. 1 | Molecular Medicine

Fig. 1

From: A Mutation Unique in Serine Protease Inhibitors (Serpins) Identified in a Family with Type II Hereditary Angioneurotic Edema

Fig. 1

Pedigree of the family with type II HANE and segregation of the BsiHKAI polymorphism

(A) The entire pedigree for the type II HANE family. Solid circles (females) and squares (males) represent affected individuals. Note the two marriages of the grandfather who had one affected daughter from each marriage. (B) Restriction fragment length polymorphism after digestion of the amplified exon eight with BsiHKAI (an isoschizomer of HgiAI). The normal PCR product is 338 bp and the BsiHKAI restriction fragments of the mutant allele are 239 bp and 99 bp in size. Lanes are numbered as in Panel A.

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