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Table 1 Peptides Generated from C1-Inh by Plasmin

From: Degradation of C1-Inhibitor by Plasmin: Implications for the Control of Inflammatory Processes

Peptide no.

Peptide sequence

C1-Inh cleavage sites (amino acids)

Location in C1-Inh model

N-terminal

NP-ATSSSSQDPESL

  

1

GVTSVSQI

Residue 194–195 (KG)

α-helix D

2

KTRMEPFHFK

Residue 284–285 (KK)

Loop

3

TRMEPFHFK

Residue 285–286 (KT)

Loop

4

MEPFHFK

Residue 287–288 (RM)

Loop

5

NSVIKV

Residue 294–295 (KN)

Loop

6

KYPVAHFIDQ

Residue 306–307 (KK)

β-sheet C (strand 3)

7

AKVGQLQLS

Residue 319–320 (KA)

β-sheet B (strand 2)

8

VGQLQLSHNL

Residue 321–322 (KV)

β-sheet B (strand 2)

9

HRLEDMEQAL

Residue 342–343 (KH)

Loop

10

AIMEKLEMSK

Residue 359–360 (KA)

α-helix H

  1. Cleavage sites that generate these peptides are indicated. Numbering is according to Bock et al. (25), i.e., from the N-terminus of the circulating protein. Glycosylated amino acids are indicated by a hyphen.