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Fig. 5 | Molecular Medicine

Fig. 5

From: Post-transcriptional Contribution of a cAMP-dependent Pathway to the Formation of α- and β/γ-Secretases-Derived Products of βAPP Maturation in Human Cells Expressing Wild-type and Swedish Mutated βAPP

Fig. 5

Effect of cAMP effectors on the secretion of Aβ40 in wtβAPP751-expressing TSM1 neuronal cell line. TSM1 neocortical neuronal cell line expressing wtβAPP751 was obtained, cultured, and stably transfected as described in Materials and Methods. Cells were treated with cAMP effectors and metabolically labeled for 7 hr then secreted Aβ40 was immunoprecipitated with FCA3340 (A) as described in Materials and Methods. Densitometric analysis (B) was performed as above. Bars correspond to the mean values of two distinct experiments and are expressed as the percent of control obtained without agent.

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Molecular Medicine

ISSN: 1528-3658