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Table 1 Infectivity of virus particles released from stably transfected CD4 + Jurkat T cell lines expressing anti-HIV-1 MA Fab3H7 intrabodies a

From: Inhibition of Early and Late Events of the HIV-1 Replication Cycle by Cytoplasmic Fab Intrabodies against the Matrix Protein, p17

Virus

Cell Line

Day of p24 Harvest

TCID50/ml

% Inhibition

HXIIIBvpu+

Vector

9

1.85 × 106

 

Fab3H7 clone 621–1

17

4.09 × 104

97.8

 

Fab3H7 clone 621–3

19

2.90 × 104

98.5

HXBIIIvpu−

Vector

15

2.60 × 106

 

Fab3H7 clone 621–1

25

4.60 × 105

82.3

 

Fab3H7 clone 621–3

20

6.30 × 106

76.0

 

Fab3H7 clone 725–1

20

1.60 × 105

93.8

 

Fab3H7 clone 725–3

20

1.16 × 105

96.0

SI primary isolate #1

Vector

15

1.80 × 106

 

Fab3H7 clone 621–1

30

1.15 × 105

93.6

 

Fab3H7 clone 621–3

30

2.80 × 104

98.5

 

Fab3H7 clone 725–1

20

1.15 × 105

93.6

 

Fab3H7 clone 725–3

20

4.00 × 104

97.7

  1. a−0.5, 0.5, and 0.2 M.O.I, of HXIIIBvpu+, HXHIBvpu−, and SI primary isolate #1 were used to infect cells respectively.