Fig. 1

Distribution of relative expression of TCR Vβ gene segments among CD4⁺ and CD8⁺ peripheral T cells from myasthenia gravis patients (■) and healthy controls (◯).

Analyses of frequency of usage of individual Vβ gene families were performed by a comparative PCR-based approach. Four out of 22 Vβs were determined to be overrepresented—importantly, in both CD4⁺ and CD8⁺ T cell subsets derived from MG patients: Vβ1 (A), Vβ13.2 (B), Vβ17 (C) and Vβ20 (D).