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Table 3 Stability of thalidomide and analogs in human plasma

From: Selection of Novel Analogs of Thalidomide with Enhanced Tumor Necrosis Factor α Inhibitory Activity

Half-Lives (t1/2) of Compounds (hr)

Thalidomide

CC-1069

CC-1104

CC-1115

1.52 ± 0.11

7.80 ± 0.66

2.57 ± 0.53

3.77 ± 0.32

  1. Human plasma (Sigma) was spiked with thalidomide or analogs and incubated at 37°C. Drug levels were determined by HPLC.
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Molecular Medicine

ISSN: 1528-3658