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Fig. 2 | Molecular Medicine

Fig. 2

From: Abnormal Activation of Glial Cells in the Brains of Prion Protein-deficient Mice Ectopically Expressing Prion Protein-like Protein, PrPLP/Dpl

Fig. 2

Gliosis of astrocytes and microglia in the brains of aged Ngsk Prnp0/0 mice. Localizations of mRNAs for GFAP and LM, and immunoreactivities to GFAP and F4/80 in the forebrains and cerebella of 92-week-old Prnp+/+, Ngsk Prnp0/0 and Tg(P) Ngsk Prnp0/0 mice are shown. Both hybridized and immunoreactive signals were localized mainly in the cerebral and cerebellar white matter. The number of positive cells and the intensity of their signals were markedly increased in the Ngsk Prnp0/0 mice compared with Prnp+/+ and Tg(P) Ngsk Prnp0/0 mice. Cc; corpus callosum, Fh; fimbria hippocampus, Gr; granular layer, Mo; molecular layer, Pu; Purkinje cell layer, Wh; cerebellar white matter. Original magnification: ×13.2 for in situ hybridization and ×25 for immunohistochemistry.

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Molecular Medicine

ISSN: 1528-3658