Fig. 3
From: ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury
Effect of high plasma cholesterol on BBB permeability following brain injury. LDLR−/− mice (striped bars) and apoE−/− mice (black bars) were fed mouse chow (chow), enriched diet (enriched) or Western Diet (western) for 2 weeks prior to cold injury to the cortex and during the 7 day healing period. (Top) The diets produced different total plasma cholesterol levels in these mice. (Bottom) Mice on these diets were sacrificed 3 hours after Evans blue injection and the dye was extracted from their brains. In the LDLR−/− mice, the increasing cholesterol levels did not affect the amount of dye in the brain while the injury-induced leakage of BBB in the apoE−/− mice increased in the presence of high plasma cholesterol.