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Table 1 Tumorigenicity and blood burden in nude mice. The inhibitory Rho family MTLn3 lines were assessed for growth 5 weeks after implantation into nude mice. The mean tumor size ± SEM of at least 3 separate experiments is shown. Colony forming assays were performed on the peripheral blood of nude mice 5 weeks after implantation with MTLn3 lines encoding the dominant inhibitory Rho proteins or control lines.

From: Rho Family GTPases Regulate Mammary Epithelium Cell Growth and Metastasis Through Distinguishable Pathways

 

5 Weeks Growth

Tumor Size Diameter (cm) (Mean ± SEM)

Cells in Blood (range)

Lung Metastasis (Mean ± SEM)

MTLn3-pCMV5

1.36 ± 0.13

78–80

26 ± 4.74

MTLn3-N17Cdc42

0

0

0

MTLn3-pEXV

1.57 ± 0.23

92–100

21 ± 1.56

MTLn3-N17Rac

0

0

0

MTLn3-N19Rho

0.49 ± 0.06

16–25

0