Table 2 Summary of the role of Rho GTPases derived from analyses of the dominant inhibitory MTLn3 lines. The ability to regulate function completely (>90%, triple arrow), partially (40–70%, double arrow), modestly (10–30% single arrow) or not detected (none).
| Â | cdc42N17 | RacN17 | RhoN19 |
|---|---|---|---|
Focal contacts and | Disruption |
| Disruption |
tyrosine phosphorylation |
| Â |
|
Protrusion/Spreading |
|
|
|
EGF-guided Chemotaxis |
|
|
|
Cellular proliferation |
|
|
|
Primary tumor growth |
|
|
|
Colony formation (CFU) (cells in blood) |
|
|
|
Lung macro-metastasis | none | none | none |
Foci formation (Soft agar) |
|
|
|
50%
50%
80%
60%
60%
20%
60%
70%
75%
10%