Fig. 5
Survival curve analysis of Tg53 rats on regular salt (0.4% NaCl) diets, Tg53-reg rats, compared with Tg53 rats on low salt (0.008% NaCl) diets from 6 months of age, Tg53-lsd rats. Lifespan is plotted in days vs. percent survival up to 300 days. Tg53-lsd rats exhibit increased survival compared with Tg53-reg rats (log rank test P < 0.0001). Since maximum probability was reached at 300 days, the Tg53-lsd rat survival experiment was terminated and hearts analyzed at this time point. Survival is decreased (log rank test P = 0.0004) in Tg53 rats (Tg53-reg) compared with nonTg Dahl S rats (nonTg-reg) on regular rat chow, corroborating earlier observations.7 Lifespan of low salt diet fed Tg53-lsd and nonTg-lsd rats are increased (multiple comparison P < 0.001) compared with regular rat chow fed Tg53-reg and nonTg-reg rats respectively.