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Fig. 4 | Molecular Medicine

Fig. 4

From: Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma

Fig. 4

Hepatic mRNA expression of signal transcription factors quantified by light cycler analysis. (a) C/EBP-β mRNA expression increased after burn and remained elevated during the study period. Insulin decreased hepatic C/EBP-β mRNA expression on the first day after thermal injury (p < 0.05). (b) Hepatic STAT-5 mRNA expression increased after the burn trauma. Insulin significantly decreased STAT-5 mRNA expression on days 1, 2, and 7 when compared to controls (p < 0.05). (c) Hepatic mRNA expression of STAT-3 increased after trauma, but no significant differences between controls and insulin could be shown. (d) Hepatic RANTES mRNA expression was decreased in the saline control and insulin groups after thermal trauma. Insulin increased RANTES mRNA, which approached normal levels 7 days posttrauma compared to rats receiving saline (p < 0.05). (e) SOCS-3 mRNA was found to be increased with burn injury. Insulin further increased hepatic mRNA expression of SOCS-3 2, 5, and 7 days after burn.*Significant difference between insulin and control (p < 0.05). Data are presented as means ± SEM.

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