Table 1 Sequence comparison of various members of the solute carrier family
THTR-1 | |||||
|---|---|---|---|---|---|
N-glycosylation | Family | a.a. | N -glycosylation | ||
A. | Consensus Site | Member | Position | Sequence | Domain |
N63 (63–65) | hTHTR-1 | 59–70 | GPDKNLTEREVF | Extracellular loop 2 (EL2) | |
mTHTR-1 | 59–70 | GPDKNLTERQVY | |||
hTHTR-2 | 41–52 | GPDKNLTSAEIT | |||
mTHTR-2 | 42–53 | EPSKNLTSPEMT | |||
haRFC1 | 52–63 | LLQQNFTIEQVT | |||
hRFC1 | 54–65 | GPDKNFTREQVT | |||
mRFC1 | 52–63 | LLERKFTKEQVT | |||
rRFC-1 | 52–63 | LLERNFTKEQVT | |||
N314 (314–316) | hTHTR-1 | 311–322 | QVVNNYTQGLWE | Transmembrane | |
mTHTR-1 | 311–322 | FQVVNYAQGLWE | domain 7 (TMD7) | ||
hTHTR-2 | 293–304 | NQVLNYVQILWD | |||
mTHTR-2 | 287–298 | NQILNYVQVLWE | |||
haRFC1 | 284–295 | YLIVYYVHVLWS | |||
hRFC1 | 282–293 | YLVVYYVHILWN | |||
mRFC1 | 282–293 | YLITYYVHVLWR | |||
rRFC-1 | 285–296 | YLITYYVHVLWL | |||
N413 (413–415) | hTHTR-1 | 410–421 | QIAANLSMERYA | Transmembrane | |
mTHTR-1 | 411–422 | QIAANLSMERYA | domain 10 (TMD10) | ||
hTHTR-2 | 393–404 | QIAVNLNVERYA | |||
mTHTR-2 | 387–398 | QIAVNLSLERYA | |||
haRFC1 | 386–397 | QIASSLSKELCA | |||
hRFC1 | 386–397 | QIASSLSKELCA | |||
mRFC1 | 379–390 | QIASSLSKELCA | |||
rRFC-1 | 379–390 | QIASSLSKELCA | |||
Family | a.a. | ||||
B. | Member | Position | TMD5 | ||
hTHTR-1 | 165–186 | TLVGFTVGSVLGQILVSVAGWS | |||
mTHTR-1 | 165–186 | TLVGFTVGSVLGGILVSVVGWS | |||
hTHTR-2 | 147–168 | TLAAYTAGSVLAQLLVSLANMS | |||
mTHTR-2 | 148–169 | TLVAYTAGSVLAQLLVSLTNLP | |||
haRFC1 | 158–179 | VLLGVFTSSVLGQVLWPLEQKS | |||
hRFC1 | 159–180 | VLLGVFTSSVLGQLLVTVGRVS | |||
mRFC1 | 158–179 | VLLGVFISSVLGQALVTVGHIS | |||
rRFC1 | 158–179 | VLLGVFISSVLGQVLVTLGGIS | |||