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Fig. 3 | Molecular Medicine

Fig. 3

From: Transgenic Mice Expressing Shb Adaptor Protein under the Control of Rat Insulin Promoter Exhibit Altered Viability of Pancreatic Islet Cells

Fig. 3

Insulin secretion of islets isolated from control CBA or Shb-transgenic mice. Isolated islets were cultured in RPMI 1640 + 10% serum for 18 hr in the absence or presence of 25 U/ml IL-1β + 1000 U/ml IFN-γ. The islets were then incubated for 60 min in 1.7 mM glucose, followed by an incubation for 60 min in 16.7 mM glucose, after which insulin secretion was determined. Data for mean ± SEM for 7 to 9 observations are given. #p < 0.01 when compared with CBA control islets in the absence of cytokines using an unpaired Students’ t-test; *p < 0.05 and ***p < 0.001 when compared with the corresponding values in the absence of cytokines using a paired Students’ t-test.

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Molecular Medicine

ISSN: 1528-3658