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Fig. 6 | Molecular Medicine

Fig. 6

From: α-Secretase ADAM10 as Well as αAPPs Is Reduced in Platelets and CSF of Alzheimer Disease Patients

Fig. 6

Quantitative analysis of α APPs in CSF of control subjects and AD patients. (A) Representative Western blot analysis performed on CSF collected from two control subjects and two AD patients with mAb 6E10, recognizing αAPPs. A 110-kDa form immunoreactive for 6E10 is present (arrowhead). Apparent molecular weight is reported on the right. (B) Quantitative analysis of 6E10 western blot are reported (control, n = 12; AD, n = 15) Immunoreactive bands were measured by computer-assisted imaging. A significant reduction in the levels of 110-kDa form was observed in AD patients (p < 0.05).

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