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Table 4 Proliferation response of PBMC from healthy individuals to 5 gp43 peptides selected by TEPITOPE program a

From: In Silico Prediction of Peptides Binding to Multiple HLA-DR Molecules Accurately Identifies Immunodominant Epitopes from gp43 of Paracoccidioides brasiliensis Frequently Recognized in Primary Peripheral Blood Mononuclear Cell Responses from Sensitized Individuals

Controlsb

gp43 (45–59)c

gp43 (94–108 c

gp43 (106–120)c

gp43 (283–298)c

gp43 (180–194)c

gp43 1 µg

PHA

0.1

1.0

10.0

0.1

1.0

10.0

0.1

1.0

10.0

0.1

1.0

10.0

0.1

1.0

10.0

c1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

234.1

c2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

439.2

c3

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

232.1

c4

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

216.4

c5

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

353.2

c6

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

545.3

  1. aOnly positive stimulation index values (SI ≥ 2) are shown. Dash (-) corresponds to SI < 2.
  2. bc = healthy control individual.
  3. cPBMC (105 cells/well) were stimulated with peptides at 0.1, 1.0, and 10.0 µM as described.
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Molecular Medicine

ISSN: 1528-3658