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Table 8 Peptide binding analysis of peptides neighboring gp43(180–195) with 9 most prevalent HLA-DR a

From: In Silico Prediction of Peptides Binding to Multiple HLA-DR Molecules Accurately Identifies Immunodominant Epitopes from gp43 of Paracoccidioides brasiliensis Frequently Recognized in Primary Peripheral Blood Mononuclear Cell Responses from Sensitized Individuals

 

Binding capacity/IC50% (nM)

  

Peptides

DR1 DRB1 *0101

DR3 DRB1 *0301

DR4w4 DRB1 *0401

DR4w15 DRB1 *0405

DR7 DRB1 *0701

DR5w11 DRB1 *1101

DR6w19 DRB1 *1302

DR2w2 B1 DRB1 *1501

DR2w2 B2 DRB5 *0101

Bound Molecules

Freqb

gp43(183–197)

13

1447

464

190

11

5.1

146

59

51

8

89%

gp43(179–199)

1.8

116

92

11

18

12

9.1

5.9

6.2

9

100%

gp43(181–195)

0.080

736

68

23

2.0

11

1.3

4.9

1.0

9

100%

gp43(180–194)

0.27

93

37

33

8.8

4.8

2.7

6.3

2.6

9

100%

  1. aThe results are expressed in IC50% (nM). Peptide binding assays were performed as described in Table 2. Bold numbers = significant affinity threshold below 1000.
  2. bFreq = frequency.
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Molecular Medicine

ISSN: 1528-3658