Fig. 6
From: Ubiquitous Induction of p53 in Tumor Cells by Antisense Inhibition of MDM2 Expression
Induction of cell death by inhibition of MDM2 expression.
Cells were treated with 200 nM AS2 or control oligonucleotide K for 24 hr and photographed. (A) Examples of cell lines undergoing significant cell death characteristic of apoptosis are shown. (B) SK-N-SH cells treated with AS2 were stained with the DNA dye DAPI to reveal nuclear fragmentation and shrinkage of apoptotic cells.