Radiation | Â | Â | Vessel origin | Host | Result | Â | Molecular | Ref |
---|---|---|---|---|---|---|---|---|
Target | Mode | Dose | Â | Â | Type | IR/Ctrl | Â | Â |
Endothelial cells | ||||||||
 | C-ion | 0.1–8 Gy | HUVEC | Transwell chamber | Migration | < 1 | αvβ3; MMP-2 | (Takahashi et al., 2003) |
 |  |  |  | Collagen | Tube formation | < 1 |  |  |
 | kV | 0.1–8 Gy |  | Transwell chamber |  | > 1 |  |  |
 |  |  |  | Collagen | Tube formation | 1 |  |  |
 | nm | 4 Gy | HUVEC | Matrigel | Tube formation | 0.8 | αvβ3 | (Abdollahi et al., 2005) |
 | nm | 8 Gy | HMEC | Matrigel | Invasion | 1 |  | (Kaliski et al., 2005) |
 | 250 kV | 6 Gy | HUVEC | Tissue culture plastic | Wound healing migration | 4 | eNOS | (Sonveaux et al., 2003) |
 |  |  | HUVEC | Matrigel | Tube formation |  |  |  |
 | 137 Cs | 3 Gy | HUVEC | Matrigel | Tube formation | 0.8 | αvβ3 | (Albert et al., 2006) |
 | 125 kV | 15 Gy | HUVEC | Tissue culture plastic | Wound healing migration | 0.6 |  | (Imaizumi et al., 2010) |
 | 6 MV | 0.5 Gy | HUVEC |  | Wound healing migration | > 1 | VEGFR | (Sofia Vala et al., 2010) |
Cancer cells | ||||||||
 | 6MV | 10 Gy | HUVEC | Transwell/CM C6 | Chemotactic migration | 2 | MMP-2 & -9 | (Parthymou et al., 2004) |
 | 6 MV | 10 Gy | CAM | CAM/C6 | angiogenesis | > 1 |  | (Parthymou et al., 2004) |
 |  |  | HUVEC | Matrigel/PC3 | Invasion | 1.9 |  | (Abdollahi et al., 2005) |
 |  | 8 Gy | HMEC | Matrigel/CM B16 | Invasion | 2.4 | MMP-2 | (Kaliski et al., 2005) |
 | 150 kV | 10 Gy | HMEC | Matrigel/CM IOMM | Tube formation | 1.4 | uPA | (Kargiotis et al., 2008) |
 | nm | 8 Gy | HMEC | T. c. plastic/CM U251 | Branching | 1.4 | MMP-2 | (Badiga et al., 2011) |
CAF | ||||||||
 | 15 MV | 18 Gy | HUVEC | Transwell/CM CAF | Migration | 0.6 |  | (Hellevik et al., 2013) |
 |  |  | HUVEC | Matrigel/CM CAF | Tube formation | 1 |  | (Hellevik et al., 2013) |
Inoculation site | ||||||||
 | 50 kV | 19 Gy | CAM | CAM/C6 | Angiogenesis | > 1(48 h) |  | (Polytarchou et al., 2004) |
 | 6 MV | 2 Gy | SCID mouse subcutis | HepG2 | Micro-vessel density | > 1 | VEGF |  |
 | 125 kV | 20 Gy | C57/Bl subcutis | Matrigel plus FGF2 | Micro-vessel density | 0.36 | FGF2 | (Imaizumi et al., 2010) |
 |  |  |  | Matrigel plus VEGF | Micro-vessel density | 0.11 | VEGF |  |
 | 6 MV | 0.5 Gy | nude mouse subcutis | Matrigel plus FGF2 | Angiogenesis | > 1 |  | (Sofia Vala et al., 2010) |
 | 125 kV | 20 Gy | mammary fat pad. | Mammary/AT1 | Micro-vessel density | 0.44 |  | (Kuonen et al., 2012b) |
Total body | ||||||||
 | 220 kV | 15 Gy | C57/Bl aortic | Tissue culture plastic | Sprouting | 0.11 | TGFΙβ | (Imaizumi et al., 2010) |
 | 6 MV | 0.5 Gy | zebra fish | Embryo | Angiogenesis | > 1 |  | (Sofia Vala et al., 2010) |
Tumor | ||||||||
 | 250 kV | 6 Gy | C57/Bl6 subcutis | LLC | Micro-vessel density | > 1 |  | (Sonveaux et al., 2003) |
 | 6MV | 8 Gy | C57/BL6 cerebrum | ALTS1C1 | Micro-vessel density | > 1 |  | (Wang et al., 2013) |
 |  |  | SCID mouse subcutis | SW410 | Micro-vessel density | 2 |  | (Timaner et al., 2015) |