Fig. 2

Bariatric surgery result in normalization of body weight, body composition, and glucose tolerance. a Body weight over time following bariatric surgery or diet-reversal. At the time of surgery (At sx) mice are 18 weeks of age with the weight of all groups statistically different from CD. The weights of both RYGB and BD-IL mice reached similar weights to CD controls approximately 4 days after surgery while DIO-Rev mice did so 4 weeks after diet transition. # p < 0.05 for DIO-SHAM, DIO-Rev, and RYGB versus CD. $ p < 0.05 for DIO-SHAM and DIO-Rev versus CD. * p < 0.05 for DIO-SHAM versus CD. b Body weight of all experimental groups at the time of surgery (At Sx) and sacrifice (At Sac). c Body composition of all experimental groups at the time of surgery (At Sx) and sacrifice (At Sac). d Blood glucose levels in surgical and control mice during an oral glucose tolerance test. e Fasting blood glucose levels (f) Glucose integrated area under the curve (AUC). a = significant difference versus DIO-SHAM. b = significant difference versus CD. p < 0.05 (n = 6–8 per group). Data are represented as mean ± SEM