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Fig. 5 | Molecular Medicine

Fig. 5

From: Total serum cholinesterase activity predicts hemodynamic changes during exercise and associates with cardiac troponin detection in a sex-dependent manner

Fig. 5

Summary Figure.The acetylcholine analog acetylthiocholine is hydrolyzed by two degrading enzymes (acetylcholinesterase and butyrylcholinestersase). Its degredation reflects the total serum cholinesterase activity referred to as Cholinergic Status (CS). CS potentially reflects upon the body’s sympathetic-parasympathetic balance with decreased levels of CS indicating prominent parasympathetic activity. In both sexes, CS was correlated with age and metabolic impairment. In women, elevated CS values predicted a hypertensive reaction during exercise and correlated with systolic blood pressure elevation rate. Most importantly, CS is positively correlated with high sensitive cardiac troponin T detection in women but inversely so in men. Heart rate recovery from exercise was inversely correlated to CS in both sexes, more significantly in women. CS is a potential new biomarker for cardiovascular disease risk stratification, autonomic nervous system function and monitoring of parasympathetic stimulation treatment strategies. ANS- Autonomic Nervous System

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Molecular Medicine

ISSN: 1528-3658