Fig. 7

Schematic model of Hsp90α regulation of HSV-1 α genes in the context of Hsp90 inhibition or Hsp90α knockdown. Hsp90 inhibition or Hsp90α siRNA induces VP16 autophagosome degradation, leading to reduced α gene transcription, and then suppressed HSV-1 replication in vitro and in vivo. Specifically, Hsp90 inhibition disrupts the interaction between VP16 and Hsp90α and then induces the degradation in an autophagy-dependent manner. Notably, Hsp90 inhibition inhibits the mTOR pathway and then activates autophagy