Fig. 1

CD44 regulates cardiac remodeling and cardiac function in the early stage of MI. A CD44 is highly expressed in the heart in the early stage of MI. Representative confocal microscopy images of CD44 (red) expressed in cardiac border zone (c, f) and infarct zone (d, e) in 1-week MI mouse hearts and normal hearts (a, b). DAPI (blue) stained nuclei and cTnT (green) labeled cardiomyocytes. Scale bars: 400 μm (upper panel); 100 μm (lower panel). B The statistical data of CD44 relative fluorescence intensity in normal hearts (Sham), infarct zone (MI-I), border zone (MI-B), and remote area (MI-B) in MI mouse hearts. n = 3. C Schematic illustration of the mouse MI experiment. D The echocardiography results of the WTSham, KOSham, WTMI, and KOMI groups 1 week post-MI. LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole. E The statistical data of left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular end-diastolic volume (LVEDV), and left ventricular end-systolic volume (LVESV) of WTSham (n = 10), KOSham (n = 11), WTMI (n = 24), and KOMI (n = 19) groups. *P < 0.05, **P < 0.01, ***P < 0.001, ns no significance. Echo, echocardiography