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Fig. 4 | Molecular Medicine

Fig. 4

From: TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre-implantation embryos

Fig. 4

TOP2A promotes migration and invasion of trophoblast cells. A The effects of TOP2A knockdown on the migration rate of JEG-3 cells was determined using a wound healing assay. B Transwell assay was used to assess migration of trophoblasts. C Invasion of trophoblasts was assessed by transwell assay. D The effect of TOP2A on the expression of invasion-related protein metalloproteinase-2 (MMP-2) was assessed. E qRT-PCR was employed to determine the effect of TOP2A knockdown on the mRNA levels of MMP2 and MMP9. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ns, no statistical difference. Scale bar: 100 μm

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Molecular Medicine

ISSN: 1528-3658