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Fig. 6 | Molecular Medicine

Fig. 6

From: Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia/reperfusion injury via miR-206/USP22 axis

Fig. 6

The effect of Exos-KLF3-AS1 on cerebral I/R injury could be overturned by miR-206 overexpression or Sirt1 knockdown. Cells transfected with miR-206 mimic or sh-Sirt1 were subjected to OGD, prior to supplemented with Exos-KLF3-AS1. A Cell viability was assessed. B TUNEL-positive cells. C The production of ROS. D The mRNA levels of MCP-1, TNFα and IL-6. E, F qRT-PCR detection of KLF3-AS1 (E) and miR-206 (F). G Sirt1 protein was determined. Values were expressed as mean ± SD of three separate determinations in the in vitro assays. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658