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Fig. 8 | Molecular Medicine

Fig. 8

From: PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control

Fig. 8

Representative schematic of the hypothesis. Change in mitochondrial PINK1 expression of DCs paralleled change in DC function and PINK1 knockout prevented function of DCs during sepsis. Previous studies have demonstrated that collective mitochondrial fragmentation which is caused by Drp1-dependent mitochondrial fission are involved in the dysfunction and apoptosis of immune cells. PINK1 has been characterized as a guide for damaged mitochondria which eliminates mitochondrial fragmentation through mitochondrial quality control. Therefore, we hypothesize PINK1 knockout prevented the function of DCs during sepsis through inhibiting mitochondrial quality control

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Molecular Medicine

ISSN: 1528-3658