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Fig. 6 | Molecular Medicine

Fig. 6

From: 4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes

Fig. 6

The effect of OI on oxidative stress gene expression and macrophage polarization. The peritoneal macrophages from healthy and diabetic mice were collected and were pretreated with 125 μM OI or NT for 2 h, followed by LPS, OI + LPS, or NT treatment. After 8-h treatment, total RNA was extracted and the expression of the M1-, M2-, and oxidative-related genes were measured by real-time PCR (n = 4 mice per group). The loading control was β-actin. A M1-related genes expression. B M2-related genes expression. C Oxidative-related genes expression. The results are shown as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001

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Molecular Medicine

ISSN: 1528-3658