Table 2 Typical pathological changes of the inner ear in the DM group compared with the non-diabetic group: animal models
Inner ear | Characteristic | Years | Author | Article |
|---|---|---|---|---|
Cochlear vascular system | ||||
SMA | Thickening of vessel wall ↑; | 2022 | Seo et al. | (8) |
lumen diameter ↑. | ||||
SV | Protrusion or condensation of marginal cells; swelling of intermediate cells; widening of the intercellular spaces. | 1986 | Tachibana et al. | (66) |
1986 | Nakae et al. | (67) | ||
Thickness of the SV decreased; density of intermediate cells decreased. | 2020 | Lee et al. | (7) | |
VSV | Basement membrane thickness ↑ | 1999 | McQueen et al. | (41) |
The organ of Corti | ||||
OHCs | Number NS | 2020 | Lee et al. | (7) |
1978 | Gladney et al. | (70) | ||
1995 | Raynor et al. | (43) | ||
Number ↓ | 1991 | Triana et al. | (68) | |
1992 | Rust et al. | (69) | ||
1986 | Nakae et al. | (67) | ||
Degeneration | 2008 | Lee et al. | (71) | |
1986 | Nakae et al. | (67) | ||
IHCs | Number NS | 2020 | Lee et al. | (7) |
Degeneration | 1986 | Nakae et al. | (67) | |
Cochlear nerve system | ||||
SGNs | Number ↓ | 2008 | Lee et al. | (71) |
2020 | Kang et al. | (73) | ||
2020 | Lee et al. | (7) | ||
Cochlear afferent nerve fibers | Number ↓; | 2020 | Kang et al. | (73) |
fiber endings are swollen and dislocated. | ||||