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Fig. 2 | Molecular Medicine

Fig. 2

From: Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis

Fig. 2

CD4 + and CD8 + T cells and their phenotypes in IMA. a Feature plot of top DE genes between ST and PB CD4 + T cells (Padj < 0.05, |Log2FC| > 0.5 calculated with Bonferroni corrected two-sided t-test). b Left: UMAP representation of the re-clustered CD4 + T cells. Right: UMAP representation of the tissue origin. c UMAP representation of TCR clones identified as Hyperexpanded (> 9), Expanded (> 1) and Singlet. d Violin plot of top DE genes between ST and PB in re-clustered Tregs (Padj < 0.05,  |Log2FC| > 0.5 calculated with Bonferroni corrected two-sided t-test). e Proportion of cells in different phases of cell cycle in all CD4 + cells in PB and ST. f Left: UMAP representation of the re-clustered CD8 + T cells. Right: UMAP representation of the tissue origin. g UMAP representation of TCR clones identified as Hyperexpanded (> 9), Expanded (> 1) and Singlet. h Feature plot of top DE genes that are different between ST and PB in CD8 + T cells (Padj < 0.05, |Log2FC| > 0.5 calculated with Bonferroni corrected two-sided t-test)

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Molecular Medicine

ISSN: 1528-3658