Fig. 1
From: Sirtuins in intervertebral disc degeneration: current understanding
Correlation between SIRT and IVDD. A Risk factors for IVDD. Various factors such as nutritional deficiencies, hyperglycemia, stress, hypoxia, stress, genetics, and immunocompromise contribute to disc degeneration. B Pathogenesis of IVDD, which mainly involves NP cell metabolism (senescence and apoptosis), inflammation, ECM degradation, and oxidative stress. C Role of SIRT in NP cell survival and activity.SIRT mainly activates autophagy, maintains intracellular homeostasis, and inhibits apoptosis