Fig. 4
From: Sirtuins in intervertebral disc degeneration: current understanding
SIRT is associated with the management of oxidative stress associated with IVDD. A SIRT1 can regulate a variety of target genes and target proteins, for example, SIRT1 can activate Nrf2, FOXO1, PGC-1α, LKB1, and RelA/p65, and SIRT1 can inhibit p53 and HIF-1α, etc., and thus plays an important role in oxidative stress injury. B SIRT3 is associated with the management of oxidative stress associated with IVDD.SIRT3 regulates the expression of antioxidant enzymes through activating FOXO3, PGC-1α, E2, and CREB.SIRT3 is associated with the management of oxidative stress associated with IVDD. SIRT3 is associated with the management of oxidative stress associated with IVDD.SIRT3 regulates the expression of antioxidant enzymes through the activation of FOXO3, PGC-1α, E2 and CREB