Table 1 Sirtuins: cellular regulators with multifaceted functions

Kanwal et al. (2019)

An experimental study

Experimental in vivo study

To determine the role of Sirt6 and mitochondrial Sirt (Sirt3)in protecting a diabetic heart from developing cardiomyopathy

In cardiomyocytes, Sirt6 downregulates Keap1 expression and inhibits the binding of Kelch-like ECH-associated protein 1 (Keap1) to Nrf2, thereby stabilizing Nrf2 and activating the transcription of Nrf2-dependent genes, including Sirt3

Sirt6 and Sirt3 regulate each other's activity, which may be critical for coordinating cellular metabolism and maintaining the health of an organism

Kuno et al. (2023)

An experimental study

Experimental in vivo and in vitro study

To investigate whether SIRT1 counteracts doxorubicin-induced cardiotoxicity by mediating the phosphorylation of Ser139 of histone H2AX, a key signal in the DNA damage response

1) endogenous SIRT1 protein in cardiomyocytes counteracts doxorubicin-induced cardiotoxicity.2) SIRT1 mediates the DDR and protects cells from apoptosis by regulating histone H2AX phosphorylation via its deacetylation

SIRT1 counteracts doxorubicin-induced cardiotoxicity by mediating H2AX phosphorylation through its deacetylation in cardiomyocytes

Lin et al. (2023)

An experimental study

Experimental in vivo and in vitro study

Discovery of a mechanism by which hepatocyte SIRT2 regulates hepatic bone crosstalk

In SIRT2-deficient hepatocytes, LRG1 levels in sEVs are upregulated, leading to increased transfer of LRG1 to bone-marrow-derived monocytes (BMDMs), and in turn, to inhibition of osteoclast differentiation via reduced nuclear translocation of NF-κB p65

Hepatocyte SIRT2 regulates pro-osteoclast signaling of NF-κB p65 in osteoblasts via the sEV-LRG1 pathway