Fig. 1
From: SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
Mechanisms underlying SALL4 regulation and function in esophageal cancer. THG-1 acts as an upstream regulator and inhibits NRBP1-induced ubiquitination of SALL4. MEIS1 downregulation significantly reduces the mRNA expression of SALL4. ILF2 facilitates the nuclear mRNA export of SALL4. SALL4 modulates the Notch and Wnt/β-catenin signaling pathways, promoting the progression, invasion and metastasis in esophageal cancer