Fig. 3
From: SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
Mechanisms underlying SALL4 regulation and function in colorectal cancer. In colorectal cancer, miR-508 and miR-219-5p suppress SALL4 expression by interacting with its 3′ UTR sequence, while miR-3622a-3p promotes SALL4 mRNA degradation as a tumor suppressor. SALL4 knockdown in CRC cells inhibits Bcl-2 expression and induces cell apoptosis. In CRC cells, SALL4 regulates Gli1 promoting the invasion and migration. SALL4 also targets β-catenin in colorectal cancer, further activating the Wnt/β-catenin pathways