Figure 2
From: Disease-Associated Prion Protein Elicits Immunoglobulin M Responses In Vivo
Optimal detection and depletion of PrPSc from homogenized brain. RML brain homogenate spiked into brain homogenate derived from Prn-Po/o mice was proteinase K (PK)-treated then incubated with 107 ICSM 35 saturated Dynabeads (upper panel). In the lower panel, ICSM 35 was omitted from the immunocomplex, keeping the other conditions identical. Representative of 3 experiments.