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Figure 5 | Molecular Medicine

Figure 5

From: Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function

Figure 5

Transcriptional activities of the natural pathologic and synthetic GRα mutants are positively correlated with their recovery t1/2 values. The maximal transcriptional activities induced by dexamethasone and recovery t1/2 values after photobleaching of GRα and the mutant R477H, V571A, D641V, G679S, V729I, I747M, L773P, (∆77-262), and (1-514) GRs are plotted at the x- and y-axes, respectively. Closed and open circles indicate the natural and synthetic mutant receptors, respectively. The correlation was tested by the linear regression method.

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Molecular Medicine

ISSN: 1528-3658