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Table 1 Profile of GR-related molecules studied

From: Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function

Mutant name

Characteristics

Kd for dexame thasone (compared with wild type GRa)

Binding to GREs

AF-2 binding to p160 coactivators

GRα WT

1

+

+

 

GRαR477H

Natural mutant, GRE-binding (−)

1

+

GRαV571A

Natural mutant

6

+

+

GRαD641V

Natural mutant

3

+

+

GRαG679S

Natural mutant

2.2

+

+

GRαV729I

Natural mutant

2–3

+

+

GRαI747M

Natural mutant, AF-2 (−)

2.1

+

GRαL773P

Natural mutant, AF-2 (−)

2.59

+

GRβ

Splicing variant, specific “LBD”

+

GRα(∆77-262)

Synthetic mutant, AF-1 (−)

1

+

+

GR(1-514)

Synthetic mutant, LBD (−)

  1. From references 35,710,12,13,23.