Mutant name | Characteristics | Kd for dexame thasone (compared with wild type GRa) | Binding to GREs | AF-2 binding to p160 coactivators |
---|---|---|---|---|
GRα WT | 1 | + | + | |
GRαR477H | Natural mutant, GRE-binding (−) | 1 | − | + |
GRαV571A | Natural mutant | 6 | + | + |
GRαD641V | Natural mutant | 3 | + | + |
GRαG679S | Natural mutant | 2.2 | + | + |
GRαV729I | Natural mutant | 2–3 | + | + |
GRαI747M | Natural mutant, AF-2 (−) | 2.1 | + | − |
GRαL773P | Natural mutant, AF-2 (−) | 2.59 | + | − |
GRβ | Splicing variant, specific “LBD” | − | + | − |
GRα(∆77-262) | Synthetic mutant, AF-1 (−) | 1 | + | + |
GR(1-514) | Synthetic mutant, LBD (−) | − | − | − |