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Table 1 Jejunal tissue levels of antioxidant system elements [superoxide dismutase (SOD, catalase (CAT) and gluthatione peroxidase (GSH-Px)] and glutathione (GSH)] in sham-operated animals, vehicle-treated I/R animals, and I/R animals treated with EPO five minutes before ischemia and at the onset of reperfusion.

From: Erythropoietin Protects the Intestine Against Ischemia/Reperfusion Injury in Rats

 

Enzymatic antioxidants

Non-enzymatic antioxidant

 

SOD (U/mg/protein)

CAT (U/mg/protein)

GSH-Px (U/mg/protein)

GSH (umol/mg/protein)

Sham

4.94 ± 1.24

43.15 ± 4.7

0.036 ± 0.007

0.381 ± 0.079

I/R

6.18 ± 0.43

16.83 ± 2.6a

0.035 ±0.010

0.275 ±0.025

EPO + I/R

5.34 ± 0.66

42.85 ± 6b

0.034 ±0.013

0.262 ± 0.022

I + EPO + R

5.15 ± 0.88

29.31 ± 4.6

0.032 ± 0.008

0.280 ±0.028

  1. aP < 0.01 vs sham.
  2. bP < 0.01 vs vehicle-treated I/R animals.
  3. Data are mean ± S.E.M. (n = 5–7 per group). Note that there is a significant increase in the CAT levels in the EPO + I/R group compared with the I/R group. Sham; intestinal I/R was not induced, I/R; intestinal I/R, EPO + I/R; rHuEPO administered five minutes before ischemia, I + EPO + R; rHuEPO administered onset of reperfusion.