Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock

Table 3A Gene Networks Upregulated Uniquely on Day One

		Panther Classifications³	D.A.V.I.D. Functional Annotation⁴
		•Pathway (P value)	•Category
		•Biological Process (P value)	•Term
Network and Central Node¹	Ingenuity Annotations²	•Molecular Function (P value)	•P value
Network 1 MAPK14	•Inflammatory disease	•Oxidative stress response (3.3E-8)	•GOTERM_BP_ALL
	•Infectious disease	•Immunity and defense (1.3E-12)	•Response to pest, pathogen or parasite
	•Cell-cell signaling	•Protein kinase (5.3E-5)	•1.9E-14
Network 2 STAT3	•Immune response	•Inflammation mediated by chemokine and cytokine signaling (2.2E-7)	•SP_PIR_KEYWORDS
	•Cellular movement		•Signal
	•Hematologic system development	•Immunity and defense (2.6E-13)	•6.6E-10
		•Cytokine receptor (1.8E-9)
Network 3 LYN	•Cell-cell signaling	•PDGF signaling pathway (1.9E-7)	•GOTERM_BP_ALL
	•Tissue morphology	•Immunity and defense (1.4E-13)	•Response to wounding
	•Cellular movement	•Signaling molecule (8.0E-6)	•1.1E-7

¹“Central node” is a generic term to describe a given network. The term corresponds to the gene node in a given network having a high degree of connectivity to other nodes in the network. The term is not intended as an indication of network function. MAPK14, mitogen-activated protein kinase 14 (a.k.a. p38 MAP kinaseα); STAT3, signal transducer and activator of transcription 3; LYN, p53/p56 lyn kinase.
²Based on Ingenuity Pathways Analysis annotations for a given network.
³Based on Panther Classification System. The most significant pathway, biological process, or molecular function (based on P value) in the Panther Classification System is provided for a given network.
⁴Based on the D.A.V.I.D. Functional Annotation Tool. The default parameters in D.A.V.I.D. were used to generate the most significant functional annotation (based on P value) for a given network.

ISSN: 1528-3658