| | | | P value |
---|
RiskaSNP/haplotype | AntiCCP+ (n = 612) | AntiCCP-(n = 111) | Control | CCP + vs. CCP-b | CCP + vs. Controlc | CCP- vs. Controld |
---|
rs11889341 | 35.2 | 34.5 | 29.7 | 0.84 | 0.001 | 0.14 |
rs7574865 | 38.8 | 38.6 | 32.9 | 0.96 | 0.001 | 0.11 |
rs8179673 | 38.9 | 40.0 | 34.0 | 0.77 | 0.005 | 0.08 |
rs10181656 | 38.9 | 40.0 | 34.2 | 0.76 | 0.007 | 0.09 |
Haplotype, TTCG | 34.2 | 32.4 | 28.5 | 0.62 | 0.0009 | 0.23 |
- aOnly 723 cases with anti-CCP data were compared with a total of 1008 controls.
- bAll alleles and haplotype had statistically significant risk for anti-CCP positive RA compared with control [ORs (95% CI) 1.29 (1.11–1.50), 1.28 (1.10–1.51), 1.24 (1.07–1.43), 1.23 (1.06–1.42), and 1.29 (1.11–1.51) in order]
- cThe distribution of risk alleles and haplotype between antiCCP positive and negative groups were not significantly different.
- dP values of the risk alleles and haplotype in the anti-CCP negative group were not statistically significant level compared with control group.