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Figure 2 | Molecular Medicine

Figure 2

From: Upregulated ATM Gene Expression and Activated DNA Crosslink-Induced Damage Response Checkpoint in Fanconi Anemia: Implications for Carcinogenesis

Figure 2

IR-induced and MMC-induced γ-H2AX foci in FANCA-mutant primary fibroblast cells compared with gene-corrected controls. (A) After 5 Gy irradiation, GM1309C and gene-corrected control cells were incubated for 2 h at 37°C and stained with anti-γ-H2AX. (B) After 1-h incubation with 3 µM MMC, GM1309C and gene-corrected control cells were washed to remove MMC, further incubated for 48 h at 37°C, and stained with anti-γ-H2AX.

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Molecular Medicine

ISSN: 1528-3658