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Figure 4 | Molecular Medicine

Figure 4

From: Upregulated ATM Gene Expression and Activated DNA Crosslink-Induced Damage Response Checkpoint in Fanconi Anemia: Implications for Carcinogenesis

Figure 4

Relative resistance to DNA crosslinker-induced cell cycle arrest and apoptosis in a TP53-mutant, patient-derived HNSCC cell line. (A) Percentage of cells arrested in G2/M as a function of NM concentration for VU974L (black) and OHSU-974 (blue). VU974L retained heightened sensitivity to NM-induced cell cycle arrest, reaching a threshold and then decreasing. By comparison, OHSU-974 exhibited a relative resistance to NM-induced cell cycle arrest. (B) Percentage of apoptotic cells as a function of NM concentration for VU974L (black) and OHSU-974 (red). VU974L underwent NM-induced apoptosis with concentrations of NM that exceeded the threshold for G2/M arrest. By contrast, OHSU-974 displayed a marked resistance to NM-induced apoptosis at the concentrations of NM tested.

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Molecular Medicine

ISSN: 1528-3658