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Figure 2 | Molecular Medicine

Figure 2

From: The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?

Figure 2

Hepatic dysfunction of the rat burn model mimics the postburn human disease state. (A) Serum aspartate amino transferase (AST) 24 and 48 h after thermal injury. (B) Serum alanine amino transferase (ALT) 24 and 48 h after thermal injury. (C) Serum albumin 24 and 48 h after thermal injury. (D) Caspase-3 activity in liver lysates as determined by successive Western blotting with active caspase-3 and actin antibodies. The data is expressed as a ratio of the two band intensities. (E) TUNEL staining of a liver section before (Control) and 24 h after thermal injury (Burn). (F) Quantified TUNEL positive cells 24 and 48 h after thermal injury. Time after injury in h is indicated. C, control; B, burn. Data presented are mean ± SEM. *P < 0.05 (Burned animals n = 8 and controls n = 4 per time point). *Significant difference between burn and control, P < 0.05. Reprinted with permission from Jeschke MG, et al. (2008) Calcium and ER Stress Mediate Hepatic Apoptosis after Burn Injury. J Cell Mol Med. Accepted for publication. [Epub ahead of print 2009 Jan 14).

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