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Figure 2 | Molecular Medicine

Figure 2

From: Role of E2F1-Cyclin E1-Cyclin E2 Circuit in Human Coronary Smooth Muscle Cell Proliferation and Therapeutic Potential of Its Downregulation by siRNAs

Figure 2

siRNA effects on cell proliferation. (A) Cell-cycle phase distribution data were obtained 3 d after siRNA transfection: a representative example relative to siE2F1-1324-treated CSMCs (donor 1) and its control is reported; BrdU FITC, Ig anti-BrdU labeled by FITC; PI, propidium-iodide staining. (B) Cumulative data for donors 1 and 2 indicate, for all siRNAs, a decrease of S-phase and an increase of G1-G0-phase cells; data for each cell-cycle phase are reported as percentage of the values measured in siGL2-treated cells and are expressed as means ± SEM, n = 9. *P < 0.001 and +P < 0.05 compared with control.

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Molecular Medicine

ISSN: 1528-3658