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Figure 2 | Molecular Medicine

Figure 2

From: Regulatory NK-Cell Functions in Inflammation and Autoimmunity

Figure 2

Immunoregulatory Functions of NK cells. Depending on the model system, NK cells were found to either accelerate or inhibit the development of autoimmune diseases. (A) NK cells could contribute to autoimmune inflammation by shaping Th1-polarized adaptive immune responses, by activating DCs, and by causing tissue destruction directly. (B) On the other hand, NK cells could be protective by editing initiator and effector cell populations such as antigen-presenting cells (APC)—including DCs, macrophages, and microglia, and autoreactive T cells via their cytotoxicity.

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